| Start: Depart JFK Airport [John F. Kennedy International Airport] (airport), New York on Local road(s) (East) | 0.1 |
| 1: Bear RIGHT (North) onto Local road(s) | 0.2 |
| 2: Merge onto Local road(s) | 0.1 |
| 3: Take Ramp onto JFK Expy towards Airport Exit / Other Terminals | 0.2 |
| |
 |
| 4: Take Ramp (RIGHT) onto I-678 [Van Wyck Expy] towards Van Wyck Expwy / Airport Exit / Return To Terminals / Long Term Parking / Rental Car Returns | 14.5 |
| |
 |
| 5: Turn RIGHT onto Ramp towards I-95 / I-278 / Cross Bronx Exp / Bruckner Exp / New England / Geo Washington Br / Triboro Br | 0.1 |
| 6: Keep STRAIGHT to stay on Ramp towards I-95 / I-278 / Cross Bronx Exp / Bruckner Exp / Geo Washington Br / Triboro Br | 0.3 |
| |
 |
| 7: At exit 19W, take Ramp (RIGHT) onto I-95 [Cross Bronx Expy] | 7.7 |
| |
 |
| |
 |
| 9: Keep LEFT onto I-95 Express Ln [New Jersey Tpke] towards I-95 South Express / New Jersey Turnpike South / I-80 / Garden State Parkway / Paterson | 2.5 |
| 10: At exit 69, take Ramp (LEFT) onto I-80 Express Ln towards I-80 / Garden State Parkway / Paterson | 4.0 |
| |
 |
| |
 |
| 12: At exit 43, take Ramp (RIGHT) onto I-80 towards I-287 / US-46 / Morristown / Mahwah | 1.0 |
| 13: Take Ramp (LEFT) onto I-80 Express Ln towards I-80 West Express | 1.0 |
| |
 |
| 14: Road name changes to I-80 | 61.9 |
| |
 |
| 15: Construction between Parsippany and Landing (WB) (September 1, 2009 - March 31, 2010) | |
| |
 |
| 16: Entering Pennsylvania | |
| |
 |
| 17: At exit 293, take Ramp (RIGHT) onto I-380 towards I-380 / Scranton | 27.6 |
| 18: Turn off onto Ramp | 0.2 |
| |
 |
| 19: Keep RIGHT to stay on Ramp towards I-81 / US-6 / Pa-347 / Binghamton | 0.4 |
| 20: At exit 188, take Ramp onto I-81 towards I-81 / US-6 W / Binghamton | 97.7 |
| |
 |
| 21: Construction near Lenoxville (NB) (October 9, 2009 - March 28, 2010) | |
| |
 |
| |
 |
| 23: Construction near Marathon (NB) (July 3, 2006 - June 30, 2010) | |
| |
 |
| 24: At exit 11, turn RIGHT onto Ramp towards RT-13 / Cortland | 0.1 |
| 25: Turn LEFT (South) onto SR-13 [Clinton Ave] | 0.9 |
| 26: Turn LEFT (South) onto US-11 [SR-13] | 0.3 |
| |
 |
| 27: Turn RIGHT (West) onto SR-13 [Port Watson St] | 10.1 |
| |
 |
| 28: Turn RIGHT (West) onto SR-13 [W Main St] | 6.0 |
| 29: Turn LEFT (South) onto SR-366 [Dryden Rd] | 3.9 |
| |
 |
| 30: Keep STRAIGHT onto SR-366 [Hoy Rd] | < 0.1 |
| End: Arrive Hoy Rd, Ithaca, NY 14850 | |
| |
 |