| Start: Depart Newark International Airport (airport), New Jersey on Local road(s) (West) | 0.3 |
| 1: Turn RIGHT (North) onto Local road(s) | 0.5 |
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| 2: Merge onto Local road(s) | 0.3 |
| 3: Keep STRAIGHT onto Ramp towards US-1-9 / RT-21 / US-22 / New Jersey Turnpike South / Newark-Elizabeth / Off-Airport Rental Cars | 0.2 |
| 4: Keep RIGHT to stay on Ramp towards US-1-9 / RT-21 / US-22 / New York-Newark / Off-Airport Rental Cars | 0.3 |
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| 5: Take Ramp onto US-1 [US-1 9] towards US-1-9 / RT-21 / US-22 / I-78 / Newark Downtown | 0.4 |
| 6: Keep LEFT onto Ramp towards RT-21 / US-22 / Newark Downtown | 0.3 |
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| 7: Take Ramp (RIGHT) onto SR-21 [McCarter Hwy] towards RT-21 / Newark | 3.0 |
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| 8: Bear RIGHT (East) onto Bridge St | 0.1 |
| 9: Road name changes to CR-508 [Harrison Ave] | 0.3 |
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| 10: Turn LEFT (North) onto N 2nd St, then immediately turn LEFT (West) onto Ramp | 0.3 |
| 11: Merge onto I-280 | 14.1 |
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| 12: Bridge work near East Newark (WB) (February 9, 2009 - October 29, 2010) | |
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| 13: Take Ramp (LEFT) onto I-80 Express Ln towards I-80 / I-280 W / Del Water Gap | 2.2 |
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| 14: Road name changes to I-80 | 61.9 |
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| 15: Construction between Parsippany and Landing (WB) (September 1, 2009 - March 31, 2010) | |
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| 16: Entering Pennsylvania | |
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| 17: At exit 293, take Ramp (RIGHT) onto I-380 towards I-380 / Scranton | 27.6 |
| 18: Turn off onto Ramp | 0.2 |
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| 19: Keep RIGHT to stay on Ramp towards I-81 / US-6 / Pa-347 / Binghamton | 0.4 |
| 20: At exit 188, take Ramp onto I-81 towards I-81 / US-6 W / Binghamton | 97.7 |
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| 21: Bridge work near Scranton (WB) (July 14, 2008 - November 30, 2009) | |
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| 22: Construction near Lenoxville (NB) (October 9, 2009 - March 28, 2010) | |
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| 24: Construction near Marathon (NB) (July 3, 2006 - June 30, 2010) | |
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| 25: At exit 11, turn RIGHT onto Ramp towards RT-13 / Cortland | 0.1 |
| 26: Turn LEFT (South) onto SR-13 [Clinton Ave] | 0.9 |
| 27: Turn LEFT (South) onto US-11 [SR-13] | 0.3 |
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| 28: Turn RIGHT (West) onto SR-13 [Port Watson St] | 10.1 |
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| 29: Turn RIGHT (West) onto SR-13 [W Main St] | 6.0 |
| 30: Turn LEFT (South) onto SR-366 [Dryden Rd] | 3.9 |
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| 31: Keep STRAIGHT onto SR-366 [Hoy Rd] | < 0.1 |
| End: Arrive Hoy Rd, Ithaca, NY 14850 | |
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