| Start: Depart La Guardia Airport (airport), New York on Local road(s) (South) | 0.1 |
| 1: Turn RIGHT (West) onto Local road(s) towards Autos and Buses | 0.3 |
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| 2: Merge onto La Guardia Rd | 0.1 |
| 3: Keep RIGHT onto Ramp towards Airport Exits | 0.3 |
| 4: Take Ramp (LEFT) onto Grand Central Pkwy towards Grand Central Pkwy West / Triboro Br | 1.8 |
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| 5: Merge onto I-278 | 3.2 |
| 6: At exit 47, take Ramp (LEFT) onto I-87 [Major Deegan Expy] towards I-87 / Maj Deegan Expwy / Albany | 3.1 |
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| 7: Reconstruction near the Bronx (NB) (November 1, 2008 - January 9, 2010) | |
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| 8: At exit 7N-S, turn RIGHT onto Ramp towards I-95 / US-1 / Cross Bronx Expwy / New Haven / Trenton | 0.2 |
| 9: Take Ramp onto I-95 [US-1] towards I-95 / US-1 / G Washington Br / Trenton | 3.1 |
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| 11: Keep LEFT onto I-95 Express Ln [New Jersey Tpke] towards I-95 South Express / New Jersey Turnpike South / I-80 / Garden State Parkway / Paterson | 2.5 |
| 12: At exit 69, take Ramp (LEFT) onto I-80 Express Ln towards I-80 / Garden State Parkway / Paterson | 4.0 |
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| 14: At exit 43, take Ramp (RIGHT) onto I-80 towards I-287 / US-46 / Morristown / Mahwah | 1.0 |
| 15: Take Ramp (LEFT) onto I-80 Express Ln towards I-80 West Express | 1.0 |
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| 16: Road name changes to I-80 | 61.9 |
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| 17: Construction between Parsippany and Landing (WB) (September 1, 2009 - March 31, 2010) | |
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| 18: Entering Pennsylvania | |
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| 19: At exit 293, take Ramp (RIGHT) onto I-380 towards I-380 / Scranton | 27.6 |
| 20: Turn off onto Ramp | 0.2 |
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| 21: Keep RIGHT to stay on Ramp towards I-81 / US-6 / Pa-347 / Binghamton | 0.4 |
| 22: At exit 188, take Ramp onto I-81 towards I-81 / US-6 W / Binghamton | 97.7 |
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| 23: Bridge work near Scranton (WB) (July 14, 2008 - November 30, 2009) | |
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| 24: Construction near Lenoxville (NB) (October 9, 2009 - March 28, 2010) | |
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| 26: Construction near Marathon (NB) (July 3, 2006 - June 30, 2010) | |
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| 27: At exit 11, turn RIGHT onto Ramp towards RT-13 / Cortland | 0.1 |
| 28: Turn LEFT (South) onto SR-13 [Clinton Ave] | 0.9 |
| 29: Turn LEFT (South) onto US-11 [SR-13] | 0.3 |
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| 30: Turn RIGHT (West) onto SR-13 [Port Watson St] | 10.1 |
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| 31: Turn RIGHT (West) onto SR-13 [W Main St] | 6.0 |
| 32: Turn LEFT (South) onto SR-366 [Dryden Rd] | 3.9 |
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| 33: Keep STRAIGHT onto SR-366 [Hoy Rd] | < 0.1 |
| End: Arrive Hoy Rd, Ithaca, NY 14850 | |
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